1,8-cineole heals cutaneous pseudomoniasis in goats: An animal model study

Abstract

Pseudomonas aeruginosa, an opportunistic bacterium is also an important pathogen in animals, resistant to various antibiotics in different ways. The purpose of the present study was to evaluate 1-8 cineole, a new antimicrobial agent derived from medicinal plants. Four male and female goats about two years of age weighing 45 kg were used. To prepare the P. aeruginosa inoculation site, a 30 cm2 area in the right and left flank and thorax region were shaved. The inoculum was injected intradermally at five sites, with 0.4 mL in a concentration of 106 CFU/mL of P. aeruginosa per site. After the induction of cutaneous pseudomoniasis, lesions in the right thoracic area were treated with 1-8 cineole, lesions in the left thoracic area treated with gentamicin ointment as a standard drug and lesions in the right flank were treated with glycerin daily until complete recovery. Daily administration of cineole and gentamicin for nine days improved skin lesions. Same as the untreated group (n=4), glycerin did not affect cutaneous lesions. The results of this study showed that 1,8-cineole, same as gentamicin, healed and improved cutaneous lesions in goats caused by Pseudomonas infection within nine days.