Facilitated osteogenesis of magnesium implant by coating of strontium incorporated calcium phosphate

Author:

Park Jung-Eun1ORCID,Jang Yong-Seok1ORCID,Seo Jae-Min23ORCID,Lee Min-Ho1ORCID

Affiliation:

1. Department of Dental Biomaterials and Institute of Biodegradable material, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University 1 , Jeonju 54896, South Korea

2. Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital 2 , Jeonju 54907, South Korea

3. 3 Department of Prosthodontics and Institute of Oral Bio-Science, School of Dentistry, Jeonbuk National University, Jeonju 54896, South Korea

Abstract

This study investigated the corrosion resistance and biocompatibility of magnesium coated with strontium-doped calcium phosphate (Sr-CaP) for dental and orthopedic applications. Sr-CaP was coated on biodegradable magnesium using a chemical dipping method. Magnesium coated with Sr-CaP exhibited better corrosion resistance than pure magnesium. Sr-CaP-coated magnesium showed excellent cell proliferation and differentiation. Additionally, new bone formation was confirmed in vivo. Therefore, Sr-CaP-coated magnesium with reduced degradation and improved biocompatibility can be used for orthopedic and dental implant applications.

Funder

Chonbuk National University Hospital

National Research Foundation of Korea

Publisher

American Vacuum Society

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Materials Science,Biomaterials,General Chemistry

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