Author:
Jonkhout Nicky,Tran Julia,Smith Martin A.,Schonrock Nicole,Mattick John S.,Novoa Eva Maria
Abstract
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other diseases. With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps.
Funder
UNSW International
Cancer Council NSW
Human Frontier Science Program
Discovery Early Career Researcher Award
Australian Research Council
National Health and Medical Research Council
Publisher
Cold Spring Harbor Laboratory
Cited by
407 articles.
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