Computational design and experimental confirmation of a disulfide-stapled YAP helixα1-trap derived from TEAD4 helical hairpin to selectively capture YAP α1-helix with potent antitumor activity
Author:
Funder
Jinggangshan University Startup Fund for Doctor Research
Jiangxi Provincial Natural Science Foundation
Natural Science Foundation of Jiangxi Province
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1007/s10822-024-00572-2.pdf
Reference50 articles.
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3. Zhou Y, Huang T, Cheng AS, Yu J, Kang W, To KF (2016) The TEAD family and its oncogenic role in promoting tumorigenesis. Int J Mol Sci 17:138
4. Hong W, Guan KL (2012) The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol 23:785–793
5. Santucci M, Vignudelli T, Ferrari S, Mor M, Scalvini L, Bolognesi ML, Uliassi E, Costi MP (2015) The Hippo pathway and YAP/TAZ-TEAD protein–protein interaction as targets for regenerative medicine and cancer treatment. J Med Chem 58:4857–4873
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