Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials
Author:
Funder
Tianjin Natural Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00432-019-03097-6.pdf
Reference52 articles.
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2. Bryant HE et al (2009) PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J 28:2601–2615. https://doi.org/10.1038/emboj.2009.206
3. Chen J, Peng H, He J, Huan X, Miao Z, Yang C (2014) Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Bioorg Med Chem Lett 24:2669–2673. https://doi.org/10.1016/j.bmcl.2014.04.061
4. Chevanne M et al (2010) Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. J Cell Physiol 222:401–410. https://doi.org/10.1002/jcp.21964
5. Coleman RL et al (2017) Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 390:1949–1961. https://doi.org/10.1016/s0140-6736(17)32440-6
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