Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review
-
Published:2022-09-24
Issue:1
Volume:13
Page:
-
ISSN:2730-6011
-
Container-title:Discover Oncology
-
language:en
-
Short-container-title:Discov Onc
Author:
Arip MasitaORCID, Tan Lee FangORCID, Jayaraj RamaORCID, Abdullah MahaORCID, Rajagopal MoganaORCID, Selvaraja MalarviliORCID
Abstract
AbstractAs the fourth most diagnosed cancer, cervical cancer (CC) is one of the major causes of cancer-related mortality affecting females globally, particularly when diagnosed at advanced stage. Discoveries of CC biomarkers pave the road to precision medicine for better patient outcomes. High throughput omics technologies, characterized by big data production further accelerate the process. To date, various CC biomarkers have been discovered through the advancement in technologies. Despite, very few have successfully translated into clinical practice due to the paucity of validation through large scale clinical studies. While vast amounts of data are generated by the omics technologies, challenges arise in identifying the clinically relevant data for translational research as analyses of single-level omics approaches rarely provide causal relations. Integrative multi-omics approaches across different levels of cellular function enable better comprehension of the fundamental biology of CC by highlighting the interrelationships of the involved biomolecules and their function, aiding in identification of novel integrated biomarker profile for precision medicine. Establishment of a worldwide Early Detection Research Network (EDRN) system helps accelerating the pace of biomarker translation. To fill the research gap, we review the recent research progress on CC biomarker development from the application of high throughput omics technologies with sections covering genomics, transcriptomics, proteomics, and metabolomics.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Endocrine and Autonomic Systems,Endocrinology,Oncology,Endocrinology, Diabetes and Metabolism
Reference101 articles.
1. Buskwofie A, David-West G, Clare CA. A review of cervical cancer: incidence and disparities. J Natl Med Assoc. 2020;112:229–32. https://doi.org/10.1016/j.jnma.2020.03.002. 2. Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL. Cervical cancer, version 3.2019. JNCCN J Natl Compr Cancer Netw. 2019;17:64–84. https://doi.org/10.6004/jnccn.2019.0001. 3. Hull R, Mbele M, Makhafola T, Hicks C, Wang SM, Reis RM, Mehrotra R, Mkhize-Kwitshana Z, Kibiki G, Bates DO, Dlamini Z. Cervical cancer in low and middle income countrie s (review). Oncol Lett. 2020;20:2058–74. https://doi.org/10.3892/ol.2020.11754. 4. Mera SL. Cervical cancer. Med Lab Sci. 1991;48:155–60. 5. Li X, Hu SY, He Y, Hernandez Donoso L, Qu KQ, Van Kriekinge G, Zhao FH. Systematic literature review of risk factors for cervical cancer in the Chinese population. Women’s Health. 2018. https://doi.org/10.1177/1745506518816599.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|