Author:
Torres Crigna Adriana,Link Barbara,Samec Marek,Giordano Frank A.,Kubatka Peter,Golubnitschaja Olga
Abstract
AbstractEndothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly relevant for physical and mental well-being; female and male health; in the modulation of senses, pain, stress reactions and drug sensitivity as well as healing processes, amongst others. Shifted ET-1 homeostasis may influence and predict the development and progression of suboptimal health conditions, metabolic impairments with cascading complications, ageing and related pathologies, cardiovascular diseases, neurodegenerative pathologies, aggressive malignancies, modulating, therefore, individual outcomes of both non-communicable and infectious diseases such as COVID-19. This article provides an in-depth analysis of the involvement of ET-1 and related regulatory pathways in physiological and pathophysiological processes and estimates its capacity as
a predictor of ageing and related pathologies,
a sensor of lifestyle quality and progression of suboptimal health conditions to diseases for their targeted prevention
and as a potent target for cost-effective treatments tailored to the person.
Funder
Rheinische Friedrich-Wilhelms-Universität Bonn
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry, medical,Health Policy,Drug Discovery