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Evaluation of combining ultrapulse CO2 with fractional CO2 laser for the treatment of atrophic scars in Asians

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Abstract

Various treatment modalities have been applied to atrophic scars. Fractional CO2 laser treatment has attracted increasingly more attention because of its quicker recovery time and fewer side effects. However, its limitation of sculpting the edge is an urgent shortcoming. In order to achieve a more effective result with fewer complications, we have integrated ultrapulse CO2 and fractional CO2 lasers to for the treatment of facial atrophic scars. The study included 25 patients (10 males and 15 females) diagnosed with moderate to severe atrophic scars between August 2020 and July 2022. All subjects underwent the same surgical treatment. The effects were assessed at baseline, 1 week, 1 month, and 3 months using photographic evidence. Objective evaluation of the results was conducted using a quartile grading scale, while the subjects’ satisfaction and any adverse events were also recorded. The patients in the study underwent more than two laser sessions (2–5), resulting in substantial improvement in their appearance. The time interval between each session was 3–6 months. The majority of the patients (19/25, 76%) had a significant or even excellent improvement. Any adverse events observed, such as erythema, superficial crusting, and PIH, were of a mild nature and temporary in duration. This treatment combined two CO2 lasers is an effective and safe choice for atrophic scars in Asians.

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References

  1. Lee Y (2009) Combination treatment of surgical, post-traumatic and post-herpetic scars with ablative lasers followed by fractional laser and non-ablative laser in Asians. Lasers Surg Med 41(2):131–140

    Article  PubMed  Google Scholar 

  2. Connolly D, Ha Linh Vu, Mariwalla K, Saedi N (2017) Acne Scarring—pathogenesis, evaluation, and treatment options. J Clin Aesthet Dermatol 10(9):12–23

    PubMed  PubMed Central  Google Scholar 

  3. Kune Lu, Cai S (2022) Efficacy and safety comparison between 1927 nm thulium laser and 2940 nm Er:YAG laser in the treatment of facial atrophic acne scarring: a prospective, simultaneous spilt-face clinical trial. Lasers Med Sci 37:2025–2031

    Article  Google Scholar 

  4. Majid I, Imran S (2014) Fractional CO2 laser resurfacing as monotherapy in the treatment of atrophic facial acne scars. J Cutan Aesthet Surg 7(2):87–92

    Article  PubMed  PubMed Central  Google Scholar 

  5. Patel L, McGrouther D, Chakrabarty K (2014) Evaluating evidence for atrophic scarring treatment modalities. J Royal Soc Med Open 5(9):1–13

    Google Scholar 

  6. Li J, Duan F, Kuang J (2023) Fractional picosecond laser for atrophic acne scars: a meta-analysis. J Cosmet Dermatol 22(8):2205–2217

    Article  PubMed  Google Scholar 

  7. Sirithanabadeekul P, Leetrakulwanna V, Suwanchinda A (2022) A novel technique in reducing sebum production and improving atrophic acne scars. J Cosmet Dermatol 21(11):5872–5879

    Article  PubMed  Google Scholar 

  8. Cucu C, Butacu AI, Niculae BD, Tiplica GS (2021) Benefits of fractional radiofrequency treatment in patients with atrophic acne scars - literature review. J Cosmet Dermatol 20(2):381–385

    Article  PubMed  Google Scholar 

  9. Sitohang IBS, Sirait SAP, Suryanegara J (2021) Microneedling in the treatment of atrophic scars: a systematic review of randomised controlled trials. Int Wound J 18(5):577–585

    Article  PubMed  PubMed Central  Google Scholar 

  10. Maas CS, Joseph JH (2019) Safety and effectiveness of microfocused ultrasound with visualization for the correction of moderate to severe atrophic acne scars. J Drugs Dermatol 18(11):1109–1114

    CAS  PubMed  Google Scholar 

  11. Huang L (2013) A new modality for fractional CO2 laser resurfacing for acne scars in Asians. Lasers Med Sc 28:627–632

    Article  Google Scholar 

  12. Lan T, Xiao Y, Tang Li, Hamblin MR, Yin R (2018) Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: a prospective study. Lasers Surg Med 50(8):844–850

    Article  PubMed  PubMed Central  Google Scholar 

  13. Artzi O, Friedman O, Al-Niaimi F, Wolf Y, Mehrabi JN (2020) Mitigation of postsurgical scars using lasers: a review. Plast Reconstr Surg Glob Open 8(4):e2746

    Article  PubMed  PubMed Central  Google Scholar 

  14. Khatri KA, Mahoney DL, McCartney MJ (2011) Laser scar revision: a review. J Cosmet Laser Ther 13:54–62

    Article  PubMed  Google Scholar 

  15. Xu Y, Deng Y (2018) Ablative fractional CO2 laser for facial atrophic acne scars. Facial Plast Surg 34(2):205–219

    Article  CAS  PubMed  Google Scholar 

  16. Ansari F, Sadeghi-Ghyassi F, Yaaghoobian B (2018) The clinical effectiveness and cost-effectiveness of fractional CO2 laser in acne scars and skin rejuvenation: a meta-analysis and economic evaluation. J Cosmet Laser Ther 20(4):248–251

    Article  PubMed  Google Scholar 

  17. Ortiz AE, Tremaine AM, Zachary CB (2010) Long-term efficacy of a fractional resurfacing device. Lasers Surg Med 42:168–170

    Article  PubMed  Google Scholar 

  18. Lin L, Liao G, Chen J, Chen X (2022) A systematic review and meta-analysis on the effects of the ultra-pulse CO2 fractional laser in the treatment of depressed acne scars. Ann Palliat Med 11(2):743–755

    Article  PubMed  Google Scholar 

  19. Husein-ElAhmed H, Steinhoff M (2021) Comparative appraisal with meta-analysis of erbium vs. CO2 lasers for atrophic acne scars. J Dtsch Dermatol Ges 19(11):1559–1568

    Article  PubMed  Google Scholar 

  20. Ting Lan BS, Xiao Y, Tang Li, Hamblin MR, Yin R (2018) Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: a prospective study. Lasers Surg Med 50(8):844–850

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wang Y, Sun Z, Cai L, Zhang F (2023) Comparative efficacy and safety of six photoelectric therapies for the atrophic acne scars: a network meta-analysis. Indian J Dermatol Venereol Leprol 89(3):353–362

    Article  PubMed  Google Scholar 

  22. Lee HS, Lee JH, Ahn GY, Lee DH, Shin JW, Kim DH, Chung JH (2008) Fractional photothermolysis for the treatment of acne scars: a report of 27 Korean patients. J Dermatol Treat 19:45–49

    Article  CAS  Google Scholar 

  23. Walgrave SE, Ortiz AE, MacFalls HT, Elkeeb L, Truitt AK, Tournas JA, Zelickson BD, Zachary CB (2009) Evaluation of a novel fractional resurfacing device for treatment of acne scarring. Lasers Surg Med 41:122–127

    Article  PubMed  Google Scholar 

  24. Elsaie ML, Ibrahim SM, Saudi W (2018) Ablative fractional 10600 nm carbon dioxide laser versus non-ablative fractional 1540 nm Erbium-glass laser in Egyptian post-acne Scar patients. J Lasers Med Sci 9(1):32–35

    Article  PubMed  Google Scholar 

  25. Barco D, Del Barrio-Díaz P (2023) Targetoid CO2 laser resurfacing: a novel and safe technique to treat ice-pick and boxcar acne scars. Lasers Med Sci 38(1):63

    Article  PubMed  Google Scholar 

  26. Abdallah MA, Gobrial CKT, Gomah SGH (2020) Whole area versus focal acne scar treatment (FAST) of post acne-scars by fractional CO2 laser: a comparative study. Int J Med 113(Suppl):1

    Google Scholar 

  27. Zhang D-D, Zhao W-Y, Fang Q-Q, Wang Z-C, Wang X-F, Zhang M-X, Yan-Yan Hu, Zheng B, Tan W-Q (2021) The efficacy of fractional CO2 laser in acne scar treatment: a meta-analysis. Dermatol Ther 34:e14539

    Article  PubMed  Google Scholar 

  28. Jin W, Li Z, Jin Z, Jin C (2020) A novel technique for treating atrophic facial scars in Asians using ultra-pulse CO2 laser. J Cosmet Dermatol 19(5):1099–1104

    Article  PubMed  Google Scholar 

  29. Sadick NS, Cardona A (2018) Laser treatment for facial acne scars: a review. J Cosmet Laser Ther 20(7–8):424–435

    Article  PubMed  Google Scholar 

  30. Galal O, Tawfik AA, Abdalla N, Soliman M (2019) Fractional CO2 laser versus combined platelet-rich plasma and fractional CO2 laser in treatment of acne scars: image analysis system evaluation. J Cosmet Dermatol 18(6):1665–1671

    Article  PubMed  Google Scholar 

  31. Mohammed GF, Al-Dhubaibi MS (2022) Triple steps acne scar revision technique: a new combination therapeutic modality for atrophic acne scars. J Cosmet Dermatol 21(10):4659–4668

    Article  PubMed  Google Scholar 

  32. Arsiwala SZ, Desai SR (2019) Fractional carbon dioxide laser: optimizing treatment outcomes for pigmented atrophic acne scars in skin of color. J Cutan Aesthet Surg 12(2):85–94

    Article  PubMed  PubMed Central  Google Scholar 

  33. Chen R, Liu Z, Zheng H, Wang M, Wang B (2022) Efficacy of combining erbium:YAG and fractional CO2 laser for the treatment of facial scarring. Eur J Dermatol 32(6):770–780

    Article  CAS  PubMed  Google Scholar 

  34. Lei Y, Li SF, Yi Ling Yu, Tan J, Gold MH (2017) Clinical efficacy of utilizing Ultrapulse CO2 combined with fractional CO2 laser for the treatment of hypertrophic scars in Asians-a prospective clinical evaluation. J Cosmet Dermatol 16:210–216

    Article  PubMed  Google Scholar 

  35. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Laser Surg Med 34:426–438

    Article  Google Scholar 

  36. Gold MH, Biron JA (2012) Combined superficial & deep fractional skin treatment for photodamaged skin—a prospective clinical trial. J Cosmet Laser Ther 14:124–132

    Article  PubMed  Google Scholar 

  37. Nitayavardhana S, Wanitphakdeedecha R, Janice NC, Ng SE, Manuskiatti W (2020) The efficacy and safety of fractional radiofrequency nanoneedle system in the treatment of atrophic acne scars in Asians. J Cosmet Dermatol 19:1636–1641

    Article  PubMed  PubMed Central  Google Scholar 

  38. Kono T, Chan HH, Groff WF, Manstein D, Sakurai H, Takeuchi M, Yamaki T, Soejima K, Nozaki M (2007) Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med 39(4):311–314

    Article  PubMed  Google Scholar 

  39. Burns AJ, editor (2007) Fractional resurfacing in plastic surgery. Aliso Viejo, CA: Medical Insight, Inc.; 2005. http://www.miinews.com/stage/pdf/Fraxel_CME_1005.pdf. July 16.

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Zhang, MX., Hu, X., Wang, Y. et al. Evaluation of combining ultrapulse CO2 with fractional CO2 laser for the treatment of atrophic scars in Asians. Lasers Med Sci 39, 89 (2024). https://doi.org/10.1007/s10103-024-04012-3

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