Author:
Luo Yiting,Li Ying,Yuan Jie
Abstract
AbstractThe pedunculopontine tegmental nucleus (PPTg) plays a vital role in sleep/wake states. There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic, and gamma-aminobutyric acidergic (GABAergic) neurons. However, the precise roles of cholinergic, glutamatergic and GABAergic PPTg cell groups in regulating sleep–wake are unknown. Recent work suggests that the cholinergic, glutamatergic, and GABAergic neurons of the PPTg may activate the main arousal-promoting nucleus, thus exerting their wakefulness effects. We review the related projection pathways and functions of various neurons of the PPTg, especially the mechanisms of the PPTg in sleep–wake, thus providing new perspectives for research of sleep–wake mechanisms.
Funder
National Natural Science Foundation of China
The Basic Research Program of Science and Technology Department of Guizhou Province
The Growth Project of Young Scientific and technological talents in the Department of Education of Guizhou Province
Doctor Starting Fund of Affiliated Hospital of Zunyi Medical University
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Neurology,Neuropsychology and Physiological Psychology,Physiology