Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery

Author:

Zhu Shibo,Tang Xiangliang,Zhang Jin,Hu Jinhua,Gao Xiaofeng,Li Dian,Jia Wei

Funder

Science and Technology Projects in Guangzhou

Guangzhou institute of Pediatrics/Guangzhou Women and Children's Medical Center

Natural Science Foundation of Guangdong Province, China

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Reference38 articles.

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2. Chen X, Chen RX, Wei WS, Li YH, Feng ZH, Tan L, Chen JW, Yuan GJ, Chen SL, Guo SJ, Xiao KH, Liu ZW, Luo JH, Zhou FJ, Xie D. PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition. Clin Cancer Res. 2018;24:6319–30. https://doi.org/10.1158/1078-0432.CCR-18-1270.

3. Cui XB, Zhang SM, Xu YX, Dang HW, Liu CX, Wang LH, Yang L, Hu JM, Liang WH, Jiang JF, Li N, Li Y, Chen YZ, Li F. PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. J Transl Med. 2016;14:137. https://doi.org/10.1186/s12967-016-0884-y.

4. Ding H, Li LX, Harris PC, Yang J, Li X. Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease. Nat Commun. 2021;12:4548. https://doi.org/10.1038/s41467-021-24799-x.

5. Erdbrugger U, Blijdorp CJ, Bijnsdorp IV, Borras FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Falcon-Perez JM, Grange C, Hill AF, Holthofer H, Hoorn EJ, Jenster G, Jimenez CR, Junker K, Klein J, Knepper MA, Koritzinsky EH, Luther JM, Lenassi M, Leivo J, Mertens I, Musante L, Oeyen E, Puhka M, van Royen ME, Sanchez C, Soekmadji C, Thongboonkerd V, van Steijn V, Verhaegh G, Webber JP, Witwer K, Yuen PST, Zheng L, Llorente A, Martens-Uzunova ES. Urinary extracellular vesicles: a position paper by the urine task force of the International Society for Extracellular Vesicles. J Extracell Vesicles. 2021;10:e12093. https://doi.org/10.1002/jev2.12093.

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