Sleep Apnea and Cardiovascular Morbidity—a Perspective

Author:

Torres Gerard,Turino Cecilia,Sapiña Esther,Sánchez-de-la-Torre Manuel,Barbé Ferran

Publisher

Springer Science and Business Media LLC

Subject

Clinical Neurology,Neurology,Pulmonary and Respiratory Medicine

Reference86 articles.

1. WHO | Cardiovascular diseases (CVDs). WHO. World Health Organization; 2017.

2. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14. https://doi.org/10.1093/aje/kws342 .

3. Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, et al. Sleep apnea. J Am Coll Cardiol. 2017;69(7):841–58. https://doi.org/10.1016/j.jacc.2016.11.069 .

4. •• Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342:1378–84. In this paper, a dose response relation between sleep apnea and the presence of hypertension has been observed in the Winsconsin Sleep Cohort. Thus, for the first time, OSA has been suggested as a risk factor for developing hypertension and other cardiovascular diseases.

5. •• Hla KM, Young T, Finn L, Peppard PE, Szklo-Coxe M, Stubbs M. Longitudinal association of sleep-disordered breathing and nondipping of nocturnal blood pressure in the Wisconsin Sleep Cohort Study. Sleep. 2008;31:795–800. Observing the same Winsconsin cohort, the researchers found a dose-response increase in development of systolic nondipping of blood pressure depending on the severity of sleep disordered breathing at baseline. This study proposed the “nocturnal systolic nondipping” as a mechanism by which sleep disordered breathing contributes to increase cardiovascular disease risk.

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