Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive

Author:

Kohlhauer M.,Pell V. R.,Burger N.,Spiroski A. M.,Gruszczyk A.,Mulvey J. F.,Mottahedin Amin,Costa A. S. H.,Frezza C.,Ghaleh B.,Murphy M. P.,Tissier R.,Krieg T.ORCID

Funder

H2020 Excellent Science

British Heart Foundation

Vetenskapsrådet

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference30 articles.

1. Boylston JA, Sun J, Chen Y, Gucek M, Sack MN, Murphy E (2015) Characterization of the cardiac succinylome and its role in ischemia–reperfusion injury. J Mol Cell Cardiol 88:73–81. https://doi.org/10.1016/j.yjmcc.2015.09.005

2. Chien GL, Wolff RA, Davis RF, van Winkle DM (1994) “Normothermic range” temperature affects myocardial infarct size. Cardiovasc Res 28:1014–1017

3. Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515:431–435. https://doi.org/10.1038/nature13909

4. Cung T-T, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guérin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit J-F, Jouve B, Motreff P, Tron C, Labeque J-N, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice M-C, Ider O, Dubois-Randé J-L, Unterseeh T, Le Breton H, Béard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M (2015) Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373:1021–1031. https://doi.org/10.1056/NEJMoa1505489

5. Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA (2002) Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol 282:H1584–H1591. https://doi.org/10.1152/ajpheart.00980.2001

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