Gut Microbiota-Mediated Alterations of Hippocampal CB1R Regulating the Diurnal Variation of Cognitive Impairment Induced by Hepatic Ischemia–Reperfusion Injury in Mice

Author:

He Zhigang,Liu Yanbo,Li Zhen,Sun Tianning,Li Zhixiao,Liu Cheng,Xiang HongbingORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Reference33 articles.

1. Spies CD, Knaak C, Mertens M, Brockhaus WR, Shadenok A, Wiebach J, Kunzmann K, Feldheiser A, Pratschke J, Muller O, Kipping V, Fabian M, Abels W et al (2021) Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: a double-blinded randomised controlled trial. Eur J Anaesthesiol 38(9):943–956. https://doi.org/10.1097/EJA.0000000000001456

2. He Z, Liu Y, Li Z, Sun T, Li Z, Manyande A, Xiang H, Xiong J (2023) Gut microbiota regulates circadian oscillation in hepatic ischemia-reperfusion injury-induced cognitive impairment by interfering with hippocampal lipid metabolism in mice. Hepatol Int. https://doi.org/10.1007/s12072-023-10509-w

3. Kim Y, Gautam S, Aseer KR, Kim J, Chandrasekaran P, Mazucanti CH, Ghosh P, O’Connell JF, Doyle ME, Appleton A, Lehrmann E, Liu QR, Egan JM (2020) Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-kappaB signaling. Cell Death Dis 11(12):1044. https://doi.org/10.1038/s41419-020-03261-8

4. Hirsch S, Hinden L, Naim MB, Baraghithy S, Permyakova A, Azar S, Nasser T, Portnoy E, Agbaria M, Nemirovski A, Golomb G, Tam J (2023) Hepatic targeting of the centrally active cannabinoid 1 receptor (CB(1)R) blocker rimonabant via PLGA nanoparticles for treating fatty liver disease and diabetes. J Controll Release 353:254–269. https://doi.org/10.1016/j.jconrel.2022.11.040

5. Fonseca C, Ettcheto M, Bicker J, Fernandes MJ, Falcao A, Camins A, Fortuna A (2023) Under the umbrella of depression and Alzheimer’s disease physiopathology: can cannabinoids be a dual-pleiotropic therapy? Ageing Res Rev 90:101998. https://doi.org/10.1016/j.arr.2023.101998

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