The Aetiology and Global Impact of Paediatric Sepsis-Reference-Cited by-同舟云学术

The Aetiology and Global Impact of Paediatric Sepsis

Published:2023-11-27 Issue:4 Volume:11 Page:204-213
ISSN:2167-4841
Container-title:Current Pediatrics Reports
language:en
Short-container-title:Curr Pediatr Rep

Author:

Bracken Abbey,Lenihan Rebecca,Khanijau Aakash,Carrol Enitan D.

Abstract

Abstract Purpose of Review This review provides an overview of paediatric sepsis, focusing on sepsis definitions in children, global aetiology of sepsis, application of biomarkers in clinical practice, and challenges of global application of current evidence. Recent Findings Clinical definitions for paediatric sepsis vary, and a validated measurement is lacking. Aetiology varies by age and geography, with differences in healthcare, vaccination, and pathogens. Biomarkers show promise but have limited translation to clinical practice, especially in children. Summary Paediatric sepsis has a significant global impact, with high mortality and long-term morbidity, particularly in low- and middle-income countries (LMICs). Adapting definitions and validating biomarkers are crucial, especially in LMICs. Global efforts are needed to improve identification and management of paediatric sepsis, along with the evolving challenges of antimicrobial resistance (AMR). A global approach is essential to address complexities and enhance outcomes for affected children worldwide.

Funder

National Institute for Health and Care Research

Publisher

Springer Science and Business Media LLC

Subject

Pediatrics, Perinatology and Child Health

Link

https://link.springer.com/content/pdf/10.1007/s40124-023-00305-3.pdf

Reference72 articles.

1. Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease study. Lancet. 2020;395(10219):200–11. First production of global estimates of sepsis data across 195 countries.

2. Carrol ED, Ranjit S, Menon K, Bennett TD, Sanchez-Pinto LN, Zimmerman JJ, Souza DC, Sorce LR, Randolph AG, Ishimine P, Flauzino de Oliveira C, Lodha R, Harmon L, Watson RS, Schlapbach LJ, Kissoon N, Argent AC; Society of Critical Care Medicine’s Pediatric Sepsis Definition Taskforce. Operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce. Pediatr Crit Care Med. 2023;24(6):e263–71. https://doi.org/10.1097/PCC.0000000000003263. Considers limitations of the sepsis-3 definitions and development of a conceptional framework for future definitions.

3. Evans IVR, Phillips GS, Alpern ER, Angus DC, Friedrich ME, Kissoon N, et al. Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis. JAMA. 2018;320(4):358–67.

4. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–55.

5. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.