Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients

Author:

Acheampong Isaac,Minadzi Difery,Laing Edwin F.,Frimpong Michael,Vivekanandan Monika M.,Yeboah Augustine,Adankwah Ernest,Aniagyei Wilfred,Arthur Joseph F.,Lamptey Millicent,Abass Mohammed K.,Kumbel Francis,Osei-Yeboah Francis,Gawusu Amidu,Debrah Linda Batsa,Owusu Dorcas O.,Debrah Alexander,Mayatepek Ertan,Seyfarth Julia,Phillips Richard O.,Jacobsen MarcORCID

Abstract

AbstractImpaired T-cell responses to mitogens and high T-cell activation marker (TAM) expression on Mycobacterium tuberculosis–specific T-cells characterize immunopathology in patients with tuberculosis (TB). In a study of patients with TB (n = 60) and asymptomatic contacts (controls, n = 37), we found that TB patients had higher CD38+ T-cell proportions specific for M. tuberculosis protein (PPDMtb), yet total proportions of PPDMtb-specific T-cells were comparable. Notably, both activated (CD38+) and total IFN-γ+ T-cells from TB patients had lower mitogen (phytohemagglutinin, PHA)-induced responses. This impaired mitogen response improved the classification efficacy of the TAM-TB assay, especially employing the PPD/PHA-induced T-cell ratio.

Funder

Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts

Publisher

Springer Science and Business Media LLC

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