Heterogeneous imaging features of Aspergillosis at 18F-FDG PET/CT

Abstract

AbstractAspergillosis is one of the most frequent fungal infections, whose morbidity can be life-threatening, especially in some categories of patients such as immunocompromised ones. It can have various clinical presentation scenarios and should be considered when making differential diagnosis in patients with pulmonary and extrapulmonary involvement. 18F-FDG PET/CT is a whole-body diagnostic technique that can help in the study of the disease, guiding the patient management thanks to the possibility to recognize infection sites and extension. The aim of this manuscript is to provide an overview of the wide spectrum of disease presentation. Literature regarding 18F-FDG PET/CT in histologically confirmed aspergillosis cases has been revised to describe all its possible features, both usual and unusual to guide imaging interpretation. 18F-FDG PET/CT is a diagnostic tool that can help in the recognition of the heterogenous infection’s presentation, allowing the clinicians to make a prompt diagnosis and to have the most accurate management of the disease. Furthermore, other PET/CT radiopharmaceutical role in Aspergillosis imaging study have been presented.