12-Lipoxygenase Induces Apoptosis of Human Gastric Cancer AGS Cells via the ERK1/2 Signal Pathway

Author:

Chen Feng-Lin,Wang Xiao-Zhong,Li Jian-Ying,Yu Jie-Ping,Huang Cai-Yun,Chen Zhi-Xin

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,Physiology

Reference23 articles.

1. Pidgeon GP, Kandouz M, Meram A, Honn KV (2002) Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res 62:2721–2727

2. Chen YQ, Duniec ZM, Liu B, Hagmann W, Gao X, Shimoji K et al (1994) Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. Cancer Res 54:1574–1579

3. Hong SH, Avis I, Vos MD, Martinez A, Treston AM, Mulshine JL (1999) Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. Cancer Res 59:2223–2228

4. Szekeres CK, Tang K, Trikha M, Honn KV (2000) Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells. J Biol Chem 275:38831–38841

5. Liu N, Sun LG, Yu HY, Zhang Y, Yang Q, Wang XP (2005) The function of ERK on Fas-mediated apoptotic signaling pathway of human gastric carcinoma cells. Zhonghua Zhong Liu Za Zhi 27:201–203

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