Affiliation:
1. Department of Anesthesiology West China Hospital of Sichuan University No. 37 Guoxue Alley, Wuhou District 610041 Chengdu Sichuan China
2. Department of Anesthesiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
3. Department of Medical Imaging West China Hospital of Sichuan University Chengdu Sichuan China
Abstract
AbstractBackgroundAcute kidney injury (AKI) is a major complication that occurs following an operation. Therefore, there is an increasing need to discover new predictors of AKI. We hypothesized that the preoperative neutrophil‐to‐lymphocyte ratio (NLR) was associated with postoperative AKI and in‐hospital mortality following noncardiac surgery.MethodsThis is a retrospective observational study of patients who underwent noncardiac surgery at Sichuan University West China Hospital from 2018 to 2020. Multivariable logistic regression was performed as the major analytic method. In addition, sensitivity and subgroup analyses were performed to validate the results.ResultsA total of 44,065 patients were included in this study. The prevalence of postoperative AKI was 5.62%, and the in‐hospital mortality was 1.58%. Multivariable analysis demonstrated that NLR ≥ 5 was independently associated with the development of postoperative AKI (OR 1.42, 1.24–1.73; P < 0.001) and in‐hospital mortality (OR 2.03, 1.63–2.52; P < 0.001). Similar results were achieved when propensity‐score matching was performed for patients with NLR ≥ 5 and < 5 on the baseline. In stratified analysis, the associations remained persistent in most subgroups. For the sensitivity analysis, we took NLR as a continuous variable and demonstrated the potential linear relationship between NLR and postoperative AKI and mortality.ConclusionsOur results indicated that preoperative NLR is associated with the prevalence of postoperative AKI and in‐hospital mortality that occur after major noncardiac surgery. These findings suggest that NLR has the potential to be a significant correlation biomarker associated with perioperative risk assessment of patients undergoing noncardiac surgeries.
Funder
Department of Science and Technology of Sichuan Province
Science and Technology Department of Sichuan Province
Cited by
1 articles.
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