Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles

Author:

Blaauwendraad Sophia M.,Voerman Ellis,Trasande Leonardo,Kannan Kurunthachalam,Santos Susana,Ruijter George J. G.,Sol Chalana M.,Marchioro Linda,Shokry Engy,Koletzko Berthold,Jaddoe Vincent W. V.,Gaillard RomyORCID

Abstract

Abstract Background Fetal exposure to bisphenols is associated with altered fetal growth, adverse birth outcomes and childhood cardio-metabolic risk factors. Metabolomics may serve as a tool to identify the mechanisms underlying these associations. We examined the associations of maternal bisphenol urinary concentrations in pregnancy with neonatal metabolite profiles from cord blood. Methods In a population-based prospective cohort study among 225 mother–child pairs, maternal urinary bisphenol A, S and F concentrations in first, second and third trimester were measured. LC–MS/MS was used to determine neonatal concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL), and carnitines in cord blood. Results No associations of maternal total bisphenol concentrations with neonatal metabolite profiles were present. Higher maternal average BPA concentrations were associated with higher neonatal mono-unsaturated alkyl-lysophosphatidylcholine concentrations, whereas higher maternal average BPS was associated with lower neonatal overall and saturated alkyl-lysophosphatidylcholine (p-values < 0.05).Trimester-specific analyses showed that higher maternal BPA, BPS and BPF were associated with alterations in neonatal NEFA, diacyl-phosphatidylcholines, acyl-alkyl-phosphatidylcholines, alkyl-lysophosphatidylcholine, sphingomyelines and acyl-carnitines, with the strongest effects for third trimester maternal bisphenol and neonatal diacyl-phosphatidylcholine, sphingomyeline and acyl-carnitine metabolites (p-values < 0.05). Associations were not explained by maternal socio-demographic and lifestyle characteristics or birth characteristics. Discussion Higher maternal bisphenol A, F and S concentrations in pregnancy are associated with alterations in neonatal metabolite profile, mainly in NEFA, PL and carnitines concentrations. These findings provide novel insight into potential mechanisms underlying associations of maternal bisphenol exposure during pregnancy with adverse offspring outcomes but need to be replicated among larger, diverse populations.

Funder

Erasmus Medisch Centrum

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Hartstichting

Diabetes Fonds

FP7 Ideas: European Research Council

Joint Programming Initiative A healthy diet for a healthy life

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Foundation for the National Institutes of Health

horizon 2020

joint programming initiative a healthy diet for a healthy life

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Biochemistry,Endocrinology, Diabetes and Metabolism

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