Transient decrease of hepatic NAD+ and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics-Reference-Cited by-同舟云学术

Transient decrease of hepatic NAD+ and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics

Published:2016-08 Issue:8 Volume:12 Page:
ISSN:1573-3882
Container-title:Metabolomics
language:en
Short-container-title:Metabolomics

Author:

Moedas Marco F.,van Cruchten Arno G.,IJlst Lodewijk,Kulik Wim,de Almeida Isabel Tavares,Diogo Luísa,Wanders Ronald J. A.,Silva Margarida F. B.

Funder

Fundação para a Ciência e a Tecnologia (PT)

Fundação para a Ciência e a Tecnologia

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://link.springer.com/content/pdf/10.1007/s11306-016-1091-9.pdf

Reference50 articles.

1. Aires, C. C. P., IJlst, L., Stet, F., Prip-Buus, C., de Almeida, I. T., Duran, M., et al. (2010). Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochemical Pharmacology, 79(5), 792–799. doi: 10.1016/j.bcp.2009.10.011 .

2. Aires, C. C. P., van Cruchten, A., IJlst, L., de Almeida, I. T., Duran, M., Wanders, R. J. A., et al. (2011). New insights on the mechanisms of valproate-induced hyperammonemia: Inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. Journal of Hepatology, 55(2), 426–434. doi: 10.1016/j.jhep.2010.11.031 .

3. Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., et al. (2011). PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metabolism, 13(4), 461–468. doi: 10.1016/j.cmet.2011.03.004 .

4. Begriche, K., Massart, J., Robin, M.-A., Borgne-Sanchez, A., & Fromenty, B. (2011). Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver. Journal of Hepatology, 54(4), 773–794. doi: 10.1016/j.jhep.2010.11.006 .

5. Bhute, V. J., & Palecek, S. P. (2015). Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells. Metabolomics, 11(6), 1779–1791. doi: 10.1007/s11306-015-0831-6 .

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