When and How to Cover for Resistant Gram-Negative Bacilli in Severe Sepsis and Septic Shock

Author:

Hanberger Håkan,Giske Christian G.,Giamarellou Helen

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

Reference83 articles.

1. •• Cornaglia G, Giamarellou H, Rossolini GM. Metallo-[beta]-lactamases: a last frontier for [beta]-lactams? Lancet Infect Dis. 2011;11(5):381–93. doi: 10.1016/s1473-3099(11)70056-1 . A comprehensive and detailed review in which the problem of the worldwide spread of metallo-β-lactamases is analyzed being a major challenge both for treatment and for infection control policies.

2. • Hawkey PM, Jones AM. The changing epidemiology of resistance. J Antimicrob Chemother. 2009;64 Suppl 1:i3–10. doi: 10.1093/jac/dkp256 . A review of new mechanism of resistance and trends in global spread of MDR bacteria including ESBLs.

3. • Freire-Moran L, Aronsson B, Manz C, et al. Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now. Drug Resistance Updates. 2011;14(2):118–24. doi: 10.1016/j.drup.2011.02.003 . This study investigated the status of the antibacterial drug development pipeline of new agents that have entered clinical development.

4. Magiorakos A, Srinivasan A, Carey R, et al. Multidrug resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2011(Accepted Article). doi: 10.1111/j.1469-0691.2011.03570.x .

5. • ECDC/EMEA Joint technical report. The bacterial challenge: time to react A call to narrow the gap between multidrug-resistant bacteria in the EU and the development of new antibacterial agents. 2009. http://ecdc.europa.eu/en/publications/Publications/0909_TER_The_Bacterial_Challenge_Time_to_React.pdf . Accessed June 10 2011. This report describes the gap between the burden of infections due to multidrug-resistant bacteria and the development of new antibiotics.

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