Cumulative Genetic Score of DRD2 Polymorphisms Is Associated with Impulsivity and Masked Semantic Priming

Abstract

AbstractIndividual differences in the magnitude of semantic priming effects are associated with executive functions (EF). Striatal dopamine has been shown to be associated with EF as well as impulsivity and could therefore be associated with differences in the magnitude of semantic priming. We investigated n = 155 individuals in an unmasked as well as in a masked semantic priming paradigm. We additionally assessed self-reported impulsivity and a cumulative genetic score (CGS) comprising six polymorphisms that have been found to be functionally relevant for the expression of the DRD2 gene. We found a significantly negative association between the DRD2 CGS and reaction time priming in the masked semantic priming paradigm. In addition, the DRD2 CGS was positively associated with self-reported impulsivity. Our findings complement previous research by showing a role of the DRD2 gene for masked semantic priming. Therefore, the investigation of genes within the dopamine system might improve our understanding of the genetic basis of impulsivity and semantic processing. Thus, the DRD2 CGS is of interest for clinical as well as experimental psychological research.