In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

Author:

Alt Andrew,Weiss Brianne,Ogden Ann Marie,Li Xia,Gleason Scott D.,Calligaro David O.,Bleakman David,Witkin Jeffrey M.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference51 articles.

1. Alt A, Weiss B, Ogden AM, Knauss JL, Oler J, Ho K, Large TH, Bleakman D (2004) Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro. Neuropharmacology 46:793–806

2. Bainbridge JG (1968) The effect of psychotropic drugs on food reinforced behavior and on food consumption. Psychopharmacologia 12:204–213

3. Barrett JE, Witkin JM (1991) Buspirone in animal models of anxiety. In: Tunnicliff G, Eison AS Taylor DP (eds) Buspirone: mechanisms and clinical aspects. Academic, New York, pp 37–79

4. Benvenga MJ, Ornstein PL, Leander JD (1995) Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons. J Pharmacol Exp Ther 175:164–170

5. Blackburn-Munro G, Bomholt SF, Erichsen HK (2004) Behavioral effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain. Neuropharmacology 47:351–362

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