Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia

Author:

Akyuva Yener,Nazıroğlu Mustafa,Yıldızhan Kenan

Funder

BSN Health, Analyses, Innovation, Consultancy, Organization, Agriculture and Industry Ltd, Goller Bolgesi Teknokenti, Isparta, Turkey

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Biochemistry

Reference68 articles.

1. Aminzadeh M, Roghani M, Sarfallah A, Riazi GH (2018) TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease. Int Immunopharmacol 54:78–85. https://doi.org/10.1016/j.intimp.2017.10.024

2. Arioz BI, Tastan B, Tarakcioglu E, Tufekci KU, Olcum M, Ersoy N, Bagriyanik A, Genc K, Genc S (2019) Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway. Front Immunol 10:1511. https://doi.org/10.3389/fimmu.2019.01511

3. Ataizi ZS, Ertilav K, Nazıroğlu M (2019) Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca(2+) influx and inflammatory cytokine molecular pathways in the docetaxel-treated mice by melatonin and selenium treatments. Metab Brain Dis 34(4):1077–1089. https://doi.org/10.1007/s11011-019-00428-x

4. Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL (2005) Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 54(2):452–461. https://doi.org/10.2337/diabetes.54.2.452

5. Cotgreave IA, Duddy SK, Kass GE, Thompson D, Moldéus P (1989) Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C? Biochem Pharmacol 38(4):649–656. https://doi.org/10.1016/0006-2952(89)90211-6

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