Abstract
Abstract
Purpose
To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status.
Methods
Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer’s Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used.
Results
We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively.
Conclusions
These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.
Implications for cancer survivors
Patients with colorectal cancer should be monitored more closely depending on the severity of their disease and comorbidities as well as the perceived health-related quality of life, and preventive measures should be established to prevent adverse outcomes and therefore to ensure that better treatment is received.
Trial registration
ClinicalTrials.gov identifier: NCT02488161.
Funder
Hezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko Jaurlaritza
Instituto de Salud Carlos III
Osasun Saila, Eusko Jaurlaritzako
Universidad del País Vasco
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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