Abstract
Abstract
Background
Over the last years, laparoscopic appendectomy has progressively replaced open appendectomy and become the current gold standard treatment for suspected, uncomplicated appendicitis. At the same time, though, it is an ongoing discussion that antibiotic therapy can be an equivalent treatment for patients with uncomplicated appendicitis. The aim of this systematic review was to determine the safety and efficacy of antibiotic therapy and compare it to the laparoscopic appendectomy for acute, uncomplicated appendicitis.
Methods
The PubMed database, Embase database, and Cochrane library were scanned for studies comparing laparoscopic appendectomy with antibiotic treatment. Two independent reviewers performed the study selection and data extraction. The primary endpoint was defined as successful treatment of appendicitis. Secondary endpoints were pain intensity, duration of hospitalization, absence from work, and incidence of complications.
Results
No studies were found that exclusively compared laparoscopic appendectomy with antibiotic treatment for acute, uncomplicated appendicitis.
Conclusions
To date, there are no studies comparing antibiotic treatment to laparoscopic appendectomy for patients with acute uncomplicated appendicitis, thus emphasizing the lack of evidence and need for further investigation.
Funder
Universitätsklinikum Würzburg
Publisher
Springer Science and Business Media LLC
Reference11 articles.
1. Stewart B, Khanduri P, McCord C, Ohene-Yeboah M, Uranues S, Vega Rivera F et al (2014) Global disease burden of conditions requiring emergency surgery. Br J Surg. 101(1):9–22
2. Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT (2015) Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 386(10000):1278–1287
3. Baum P, Diers J, Lichthardt S, Kastner C, Schlegel N, Germer CT, Wiegering A (2019) Originalarbeit Sterblichkeit und Komplikationen nach viszeralchirurgischen Operationen. Dtsch Arztebl Int. 116(44):739–746
4. Jaschinski T, Mosch CG, Eikermann M, Neugebauer EAM, Sauerland S (2018) Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2018(11)
5. Talha A, El-Haddad H, Ghazal AE, Shehata G (2020) Laparoscopic versus open appendectomy for perforated appendicitis in adults: randomized clinical trial. Surg Endosc. 34(2):907–914
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献