Anti-inflammatory properties of Doxycycline and Minocycline in experimental models: an in vivo and in vitro comparative study

Author:

Leite Liz M.,Carvalho Antônio Germano G.,Tavares Ferreira Pollyanna L. F.,Pessoa Igor Xavier,Gonçalves Danilo O.,de Araújo Lopes Amanda,dos Santos Góes Jean Guilherme,de Castro Alves Victor Costa,Leal Luzia Kalyne A. M.,Brito Gerly Anne,Viana Glauce S. B.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Immunology

Reference52 articles.

1. Aladakatti SV, Patil PA, Vivek V (2008) Influence of tetracyclines on inflammation and their interaction with aspirin in male Wistar rats. Pharmacology online 3:808–819

2. Alano CC, Kauppinen TM, Valls AV, Swanson RA (2006) Minocycline inhibits poly (ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci USA 103:9685–9690

3. Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB (1996) A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 93:14014–14019

4. Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM (2002) Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 52:54–61

5. Attur MG, Patel RN, Patel PD, Abramson SB, Amin AR (1999) Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. J Immunol 162:3160–3167

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