A decreasing CD4/CD8 ratio over time and lower CSF-penetrating antiretroviral regimens are associated with a higher risk of neurocognitive deterioration, independently of viral replication-Reference-Cited by-同舟云学术

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A decreasing CD4/CD8 ratio over time and lower CSF-penetrating antiretroviral regimens are associated with a higher risk of neurocognitive deterioration, independently of viral replication

Published:2016-11-04 Issue:2 Volume:23 Page:216-225
ISSN:1355-0284
Container-title:Journal of NeuroVirology
language:en
Short-container-title:J. Neurovirol.

Author:

Vassallo Matteo,Fabre R.,Durant J.,Lebrun-Frenay C.,Joly H.,Ticchioni M.,DeSalvador F.,Harvey-Langton A.,Dunais B.,Laffon M.,Cottalorda J.,Dellamonica P.,Pradier C.

Funder

Abbott Fund

GlaxoSmithKline

Boehringer Ingelheim

Gilead Sciences

Janssen Research and Development

Merck

Publisher

Springer Science and Business Media LLC

Subject

Virology,Cellular and Molecular Neuroscience,Clinical Neurology,Neurology

Link

http://link.springer.com/content/pdf/10.1007/s13365-016-0490-z.pdf

Reference50 articles.

1. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799

2. Autran B, Carcelain G, Li TS, Blanc C, Mathez D, Tubiana R, Katlama C, Debré P, Leibowitch J (1997) Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277:112–116

3. Blackstone K, Moore DJ, Franklin DR, Clifford DB, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simspon DM, Ellis RJ, Atkinson JH, Grant I, Heaton RK for the CHARTER Group (2012) Defining neurocognitive impairment in HIV: deficit scores versus clinical ratings. Clin Neuropsychol 26. doi: 10.1080/13854046.2012.694479

4. Caby F, Guihot A, Lambert-Niclot S, Guiguet M, Boutolleau D, Agher R, Valantin MA, Tubiana R, Calvez V, Marcelin AG, Carcelain G, Autran B, Costagliola D, Katlama C (2016) Determinants of a low CD4/Cd8 ratio in HIV-1-infected individuals despite long-term viral suppression. Clin Infect Dis

5. Chun TW, Justement JS, Pandya P, Hallahan CW, McLaughlin M, Liu S, Ehler LA, Kovacs C, Fauci AS (2002) Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J Infect Dis 185:1672–1676

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