Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Drug Discovery,Biochemistry,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s13238-016-0353-7.pdf
Reference90 articles.
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2. Appendino G et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br J Pharmacol 139:1417–1424. doi: 10.1038/sj.bjp.0705387
3. Appendino G et al (2005) The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination. J Med Chem 48:4663–4669. doi: 10.1021/jm050139q
4. Barth P, Schonbrun J, Baker D (2007) Toward high-resolution prediction and design of transmembrane helical protein structures. Proc Natl Acad Sci USA 104:15682–15687. doi: 10.1073/pnas.0702515104
5. Bevan S, Szolcsanyi J (1990) Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharm Sci 11:330–333
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