Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?

Author:

Cserni GáborORCID,Sejben Anita

Abstract

AbstractDuctal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (DCIS). First it considers differences between low and high grade DCIS, and then it looks at several grading schemes and highlights how different these are, not only in the features considered for defining a given grade but also in their wording of a given variable seen in the grade in question. Rather than being fully comprehensive, the review aims to illustrate the inconsistencies. Reproducibility studies on grading mostly suggestive of moderate agreement on DCIS differentiation are also illustrated. The need for a well structured, more uniform and widely accepted language for grading DCIS is urged to avoid misunderstanding based misclassifications and improper treatment selection.

Funder

National Research, Development and Innovation Office

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine,Pathology and Forensic Medicine

Reference40 articles.

1. Wilkerson PM, Dedes KJ, Lopez-Garcia MA, Geyer FC, Reis-Filho JS (2011) The molecular evolution of breast cancer precursors and risk indicators. In: Kahán Z, Tot T (eds) Breast cancer, a heterogeneous disease entity. The very early stages. Springer Science+Business Media, Dordrecht, pp 89–117

2. Elston CW, Ellis IO, Pathological prognostic factors in breast cancer. I (1991) The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19:403–410

3. Amendoeira I, Apostolikas N, Bellocq JP, Bianchi S, Boecker W, Borisch B, Bussolati G, Connolly CE, Cserni G, Decker T, Dervan P, Drijkoningen M, Ellis IO, Elston CW, Eusebi V, Faverly D, Heikkila P, Holland R, Kerner H, Kulka J, Jacquemier J, Lacerda M, Martinez-Penuela J, De Miguel C, Nordgren H, Peterse JL, Rank F, Regitnig P, Reiner A, Sapino A, Sigal-Zafrani B, Tanous AM, Thorstenson S, Zozaya E, Wells CA, EC Working Group on Breast Screening Pathology (2006) Quality assurance guidelines for pathology. In: Perry N, Broeders M, de Wolf C, Törnberg S, Holland R, von Karsa L (eds) European guidelines for quality assurance in breast cancer screening and diagnosis, 4th edn. European Comission, Luxemburg, pp 219–311

4. Ellis IO, Carder P, Hales S, Lee AHS, Pinder SE, Rakha E, Al-Sam S, Deb R, Hanby A, Liebmann R, Provenzano E, Rowlands D, Wells CA, Anderson N, Girling A, Ibrahim M, Mallon E, Quinn C (2016) Pathology reporting of breast disease in surgical excision specimens incorporating the dataset for histological reporting of breast cancer. The Royal College of Pathologists. https://www.rcpath.org/uploads/assets/uploaded/c5a73c7a-50a4-4077-8815c49abbcbc1f1.pdf. Accessed 13 May 2019

5. Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Tan LK, Weaver DL, Winer E (2009) Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med 133:15–25

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3