Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
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Published:2024-01
Issue:1
Volume:50
Page:68-78
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ISSN:0342-4642
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Container-title:Intensive Care Medicine
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language:en
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Short-container-title:Intensive Care Med
Author:
Pickkers PeterORCID, Angus Derek C., Bass Kristie, Bellomo Rinaldo, van den Berg Erik, Bernholz Juliane, Bestle Morten H., Doi Kent, Doig Chistopher J., Ferrer Ricard, Francois Bruno, Gammelager Henrik, Pedersen Ulf Goettrup, Hoste Eric, Iversen Susanne, Joannidis Michael, Kellum John A., Liu Kathleen, Meersch Melanie, Mehta Ravindra, Millington Scott, Murray Patrick T., Nichol Alistair, Ostermann Marlies, Pettilä Ville, Solling Christoffer, Winkel Matthias, Young Paul J., Zarbock Alexander, Carter Angus, Fries Dietmar, Eller Philip, Gérard Ludovic, DeSchryver Nicolas, Diltoer Elisabeth, Huberlant Vincent, Michaux Isabelle, Honore Patrick, Fivez Tom, Doig Christopher, Wood Gordon, Boyd John, Turgeon Alexis, Kamper Maj, Strøm Thomas, Iversen Sussanne, Gammelager Hendrik, Rasmussen Bodil Steen, Sølling Christoffer Grant, Mæller Morten Hyllander, Groefte Thorbjoern, Dey Nilanjan, Pedersen Ulf Gøttrup, Valkonen Mila, Uusalo Panu, Jalkanen Ville, Meziani Ferhat, Lemarie Jermie, Plantefeve Gaetan, Bachoumas Konstantimos, Dufour Jean Louis, Fedou Anne-Laure, Asfar Pierre, Monnet Xavier, Vinsonneau Christophe, Gibot Sebastien, Guitton Christophe, Quenot Jean-Pierre, Muller Gregoire, Lefrant Jean Yves, Mercier Emmanuelle, Mebazaa Alexandre, Kortgen Andreas, Fichtner Sebastian, Kluge Stefan, Marx Gernot, Martin-Loeches Ignatio, McNicolas Bairbre, Kamohara Hidenobu, Harada Masahiro, Nakagami Takuo, Adachi Shingo, Ota Kohei, Furuya Ryo, Tsuruoka Ayumu, Mizushima Yasuaki, Inoue Satoki, Tuinman Pieter, Wim Roozendaal F, Beishuizen Bert, Hoiting Oscar, Dormans Tom, Van Zanten Arthur, Young Paul, Williams Anthony, McArthur Colin, Twardowski Pawel, McGuinness Shay, Roca Ricard Ferrer, Cardenas Carol Lorencio, Perez Anna Navas, Sagasti Fernando Martinez, Welters Ingeborg, Wise Matt, Waddy Sam, MacCallum Niall, Murugan Raghaven, Gomez Hernando, Busse Larry, Boldt David, Bernard Andrew, Files Daniel, Margolis Benjamin, Mosier Jarrod, Truwit Jonathon, Zamora Felix, Davison Danielle, Exline Matthew, Nielsen Nathan, Hite Duncan,
Publisher
Springer Science and Business Media LLC
Subject
Critical Care and Intensive Care Medicine
Reference33 articles.
1. Pickkers P, Angus DC, Arend J, Bellomo R, van den Berg E, Bernholz J, Bestle M, Broglio K, Carlsen J, Doig CJ, Ferrer R, Joannidis M, Francois B, Doi K, Kellum JA, Laterre PF, Liu K, Mehta RL, Murray PT, Ostermann M, Pettilä V, Richards S, Young P, Zarbock A, Kjølbye AL (2023) Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury. BMJ Open 13:e065613 2. Wen X, Peng Z, Kellum JA (2011) Pathogenesis of acute kidney injury: effects of remote tissue damage on the kidney. Contrib Nephrol 174:129–137 3. Gomez H, Ince C, De Backer D, Pickkers P, Payen D, Hotchkiss J, Kellum JA (2014) A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock 41:3–11 4. Verma SK, Molitoris BA (2015) Renal endothelial injury and microvascular dysfunction in acute kidney injury. Semin Nephrol 35:96–107 5. Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, Reis T, Rimmelé T, Bagshaw SM, Bellomo R, Cantaluppi V, Deep A, De Rosa S, Perez-Fernandez X, Husain-Syed F, Kane-Gill SL, Kelly Y, Mehta RL, Murray PT, Ostermann M, Prowle J, Ricci Z, See EJ, Schneider A, Soranno DE, Tolwani A, Villa G, Ronco C, Forni LG (2023) Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol 19:401–417
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