A vision of 14 T MR for fundamental and clinical science
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Published:2023-04-10
Issue:2
Volume:36
Page:211-225
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ISSN:1352-8661
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Container-title:Magnetic Resonance Materials in Physics, Biology and Medicine
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language:en
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Short-container-title:Magn Reson Mater Phy
Author:
Bates Steve, Dumoulin Serge O., Folkers Paul J. M., Formisano Elia, Goebel Rainer, Haghnejad Aidin, Helmich Rick C., Klomp Dennis, van der Kolk Anja G., Li Yi, Nederveen Aart, Norris David G.ORCID, Petridou Natalia, Roell Stefan, Scheenen Tom W. J., Schoonheim Menno M., Voogt Ingmar, Webb Andrew
Abstract
Abstract
Objective
We outline our vision for a 14 Tesla MR system. This comprises a novel whole-body magnet design utilizing high temperature superconductor; a console and associated electronic equipment; an optimized radiofrequency coil setup for proton measurement in the brain, which also has a local shim capability; and a high-performance gradient set.
Research fields
The 14 Tesla system can be considered a ‘mesocope’: a device capable of measuring on biologically relevant scales. In neuroscience the increased spatial resolution will anatomically resolve all layers of the cortex, cerebellum, subcortical structures, and inner nuclei. Spectroscopic imaging will simultaneously measure excitatory and inhibitory activity, characterizing the excitation/inhibition balance of neural circuits. In medical research (including brain disorders) we will visualize fine-grained patterns of structural abnormalities and relate these changes to functional and molecular changes. The significantly increased spectral resolution will make it possible to detect (dynamic changes in) individual metabolites associated with pathological pathways including molecular interactions and dynamic disease processes.
Conclusions
The 14 Tesla system will offer new perspectives in neuroscience and fundamental research. We anticipate that this initiative will usher in a new era of ultra-high-field MR.
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Biophysics
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