Author:
Tudu Champa Keeya,Bandyopadhyay Anustup,Kumar Manoj,Radha ,Das Tuyelee,Nandy Samapika,Ghorai Mimosa,Gopalakrishnan Abilash Valsala,Proćków Jarosław,Dey Abhijit
Abstract
Abstract
Cryptolepine (1,5-methyl-10H-indolo[3,2-b]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr (family: Periplocaceae), is associated with the suppression of cancer and protozoal infections. Cryptolepine also exhibits anti-bacterial, anti-fungal, anti-hyperglycemic, antidiabetic, anti-inflammatory, anti-hypotensive, antipyretic, and antimuscarinic properties. This review of the latest research data can be exploited to create a basis for the discovery of new cryptolepine-based drugs and their analogues in the near future. PubMed, Scopus, and Google Scholar databases were searched to select and collect data from the existing literature on cryptolepine and their pharmacological properties. Several in vitro studies have demonstrated the potential of cryptolepine A as an anticancer and antimalarial molecule, which is achieved through inhibiting DNA synthesis and topoisomerase II. This review summarizes the recent developments of cryptolepine pharmacological properties and functional mechanisms, providing information for future research on this natural product.
Funder
Jarosław Proćków received the funds for open access publication fee from the Ministry of Education and Science, Warsaw, Poland.
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
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