Abstract
Abstract
Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection.
Funder
Albert-Ludwigs-Universität Freiburg im Breisgau
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Reference135 articles.
1. Abt MC, McKenney PT, Pamer EG (2016) Clostridium difficile colitis: pathogenesis and host defence. Nat Rev Microbiol 14:609–620
2. Aktories K (2011) Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol 9:487–498
3. Aktories K, Hall A (1989) Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins. Tips 10:415–418
4. Aktories K, Bärmann M, Ohishi I, Tsuyama S, Jakobs KH, Habermann E (1986) Botulinum C2 toxin ADP-ribosylates actin. Nature 322:390–392
5. Aktories K, Weller U, Chhatwal GS (1987) Clostridium botulinum type C produces a novel ADP- ribosyltransferase distinct from botulinum C2 toxin. FEBS Lett 212:109–113
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献