Novel mannich-based derivative of 2-mercaptobenzimidazole (AK7): a new candidate for the treatment of inflammatory arthritis owing to its NF-κB1 inhibitory potential

Author:

Kamran Gagun,Kharl Hafiz Amir Ali,Malik Muhammad Nasir HayatORCID,Younis Waqas,Nadeem Humaira,Zubair Aymun Madni,Malik Muhammad Atif Hayat,Jahan Shah,Ahmed Ishtiaq,Shabbir Ramla,Akram Asma,Anjum Irfan,Atif Muhammad,Raza Moosa,Kamla Gull e Zahra

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference46 articles.

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2. AL-Mousawi ZA, AL-Hamed HA, Ali SA (2020) Effect of ethanolic extract of curcumin on physiological and biochemical parameters in complete Freund’s adjuvant induced arthritic rats. Biochem Cell Arch 20:2537–2543

3. Asquith DL, Miller AM, McInnes IB, Liew FY (2009) Animal models of rheumatoid arthritis. Eur J Immunol 39:2040–2044

4. Brentano F, Kyburz D, Schorr O, Gay R, Gay S (2005) The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 233:90–96

5. Cai L, Li CM, Chen WN, Qiu YY, Guo YL, Li R (2019) Penta-acetyl geniposide induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats in vitro, associated with inhibition of NF-kappaB activation. Pharmacol Rep 71:1006–1013

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