Abstract
AbstractTooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.
Funder
National Key R&D Program of China
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Sun Yat-sen University
Science and Technology Program of Guangzhou
Young Elite Scientist Sponsorship Program by CAST
Publisher
Springer Science and Business Media LLC
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