Abstract
AbstractLung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways. It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences, bearing overall mortality to incidence ratio of 0.87. The dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as bionanotechnology. This review article deliberates insights and apprehensions on the recent prologue of nanobioengineering and bionanotechnology as an approach for the clinical management of lung cancer. The role of nanobioengineered (bio-nano) tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis, diagnosis, therapeutics, and theranostics for lung cancer management has been discussed. Bioengineered, bioinspired, and biomimetic bio-nanotools of considerate translational value have been reviewed. Perspectives on existent oncostrategies, their critical comparison with bio-nanocarriers, and issues hampering their clinical bench side to bed transformation have also been summarized.
Publisher
Springer Science and Business Media LLC
Subject
Electrical and Electronic Engineering,Surfaces, Coatings and Films,Electronic, Optical and Magnetic Materials
Reference353 articles.
1. F. Bray, J. Ferlay, I. Soerjomataram, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J. Clin. (2018). https://doi.org/10.3322/caac.21492
2. American Cancer Society, Cancer Facts & Figures 2018, 1–71 (2018)
3. A.M. Cryer, A.J. Thorley, Nanotechnology in the diagnosis and treatment of lung cancer. Pharmacol. Ther. 198, 189–205 (2019). https://doi.org/10.1016/j.pharmthera.2019.02.010
4. G. Holdridge, E. Kousvelari, S.-S. Lim, M. Roco, J. Scholss, NNI workshop report on nanobiotechnology (2003)
5. K. Willow, J.A. Holland, Lung cancer: types, survival rates, and more. https://www.healthline.com/health/lung-cancer-stages-survival-rates. Accessed 4 Mar 2020
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