Author:
Schneider Susanne A.,Alcalay Roy N.
Abstract
AbstractIn recent years, numerous clinical trials for disease modification in Parkinson’s disease (PD) have failed, possibly because of a “one-size-fits all” approach. Alternatively, a precision medicine approach, which customises treatments based on patients’ individual genotype, may help reach disease modification. Here, we review clinical trials that target genetic forms of PD, i.e., GBA-associated and LRRK2-associated PD. In summary, six ongoing studies which explicitely recruit GBA-PD patients, and two studies which recruit LRRK2-PD patients, were identified. Available data on mechanisms of action, study design, and challenges of therapeutic trials are discussed.
Funder
Medizinischen Fakultät, Ludwig-Maximilians-Universität München
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology,Neurology
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