Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers
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Published:2020-04-21
Issue:8
Volume:267
Page:2296-2300
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ISSN:0340-5354
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Container-title:Journal of Neurology
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language:en
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Short-container-title:J Neurol
Author:
Gersel Stokholm Morten, Garrido Alicia, Tolosa Eduardo, Serradell Mónica, Iranzo Alex, Østergaard Karen, Borghammer Per, Møller Arne, Parbo Peter, Stær Kristian, Brooks David J., Martí Maria José, Pavese NicolaORCID
Abstract
AbstractNeuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.
Funder
Sundhed og Sygdom, Det Frie Forskningsråd
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology
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