Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson’s Disease
-
Published:2023-10-19
Issue:
Volume:
Page:
-
ISSN:1931-7557
-
Container-title:Brain Imaging and Behavior
-
language:en
-
Short-container-title:Brain Imaging and Behavior
Author:
Donahue Erin Kaye,Foreman Ryan Patrick,Duran Jared Joshua,Jakowec Michael Walter,O’Neill Joseph,Petkus Andrew J.,Holschneider Daniel P.,Choupan Jeiran,Van Horn John Darrell,Venkadesh Siva,Bayram Ece,Litvan Irene,Schiehser Dawn M,Petzinger Giselle Maria
Abstract
AbstractPerivascular spaces (PVS), fluid-filled compartments surrounding brain vasculature, are an essential component of the glymphatic system responsible for transport of waste and nutrients. Glymphatic system impairment may underlie cognitive deficits in Parkinson’s disease (PD). Studies have focused on the role of basal ganglia PVS with cognition in PD, but the role of white matter PVS is unknown. This study examined the relationship of white matter and basal ganglia PVS with domain-specific and global cognition in individuals with PD. Fifty individuals with PD underwent 3T T1w magnetic resonance imaging (MRI) to determine PVS volume fraction, defined as PVS volume normalized to total regional volume, within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of global cognitive function (Montreal Cognitive Assessment, and global cognitive composite score), and cognitive-specific domains (executive function, memory, visuospatial function, attention, and language). Higher white matter rostral middle frontal PVS was associated with lower scores in both global cognitive and visuospatial function. In the basal ganglia higher PVS was associated with lower scores for memory with a trend towards lower global cognitive composite score. While previous reports have shown that greater amount of PVS in the basal ganglia is associated with decline in global cognition in PD, our findings suggest that increased white matter PVS volume may also underlie changes in cognition.
Funder
University of Southern California
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Psychiatry and Mental health,Cellular and Molecular Neuroscience,Neurology (clinical),Cognitive Neuroscience,Neurology,Radiology, Nuclear Medicine and imaging
Reference43 articles.
1. Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., Ffytche, D. H., Weintraub, D., & Ballard, C. (2017). Cognitive decline in Parkinson Disease. Nature Reviews Neurology, 13(4), 217–231. https://doi.org/10.1038/nrneurol.2017.27. 2. Aarsland, D., Batzu, L., Halliday, G. M., Geurtsen, G. J., Ballard, C., Chaudhuri, R., K., & Weintraub, D. (2021). Parkinson disease-associated cognitive impairment. Nature Reviews Disease Primers, 7(1), 47. https://doi.org/10.1038/s41572-021-00280-3. 3. Benjamin, P., Trippier, S., Lawrence, A. J., Lambert, C., Zeestraten, E., Williams, O. A., Patel, B., Morris, R. G., Barrick, T. R., MacKinnon, A. D., & Markus, H. S. (2018). Lacunar infarcts, but not perivascular spaces, are predictors of Cognitive decline in Cerebral Small-Vessel Disease. Stroke, 49(3), 586–593. https://doi.org/10.1161/STROKEAHA.117.017526. 4. Cabeen, R. P. (2020, May 6). Quantitative Imaging Toolkit: Software for Interactive 3D Visualization, Data Exploration, and Computational Analysis of Neuroimaging Datasets. Ryan Cabeen. /about/publication/cabeen-2018-quantitative/. 5. Chen, S., Shao, L., & Ma, L. (2021). Cerebral edema formation after Stroke: Emphasis on blood-brain barrier and the lymphatic drainage system of the brain. Frontiers in Cellular Neuroscience, 15, 716825. https://doi.org/10.3389/fncel.2021.716825.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|