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Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions

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Abstract

Major Depressive Disorder (MDD) with childhood maltreatment is a prevalent clinical phenotype. Prior studies have observed abnormal hippocampal activity in MDD patients, considering the hippocampus as a single nucleus. However, there is limited research investigating the static and dynamic changes in hippocampal subregion functional connectivity (FC) in MDD patients with childhood maltreatment. Therefore, we employed static and dynamic FC analyses using hippocampal subregions, including the anterior hippocampus and posterior hippocampus, as seed regions to investigate the neurobiological alterations associated with MDD resulting from childhood maltreatment. This study involved four groups: MDD with (n = 48) and without childhood maltreatment (n = 30), as well as healthy controls with (n = 57) and without (n = 46) childhood maltreatment. Compared to MDD patients without childhood maltreatment, those with childhood maltreatment exhibit altered FC between the hippocampal subregion and multiple brain regions, including the anterior cingulate gyrus, superior frontal gyrus, putamen, calcarine gyrus, superior temporal gyrus, angular gyrus, and supplementary motor area. Additionally, dynamic FC between the right medial-2 hippocampal head and the right calcarine gyrus shows a positive correlation with childhood maltreatment across all its subtypes. Moreover, dFC between the right hippocampal tail and the left angular gyrus moderates the relationship between childhood maltreatment and the depression severity. Our findings of distinct FC patterns within hippocampal subregions provide new clues for understanding the neurobiological basis of MDD with childhood maltreatment.

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Acknowledgements

We would like to acknowledge all authors of the included articles for their prompt replies about our questions about their studies, and are grateful to reviewers for their suggestions.

Funding

This work was supported by the Guangdong Natural Science Foundation, China (2015A030313800 to HP) and the Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital (GBH2014-ZD04 to HP). The funding source had no role in the study design, analysis or interpretation of data or in the preparation of the report or decision to publish.

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  1. Huiqin Nie and Tong Yu contributed to this work equally.

Authors and Affiliations

  1. Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510370, China

    Huiqin Nie, Tong Yu, Yurong Zou, Jinrou Xia, Qianyi Luo & Hongjun Peng

  2. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China

    Qianyi Luo & Hongjun Peng

  3. Department of Publicity and Health Education, Shenzhen Longhua District Central Hospital, Shenzhen, 518000, China

    Yuhong Li

  4. The Zhongshan Torch Hi-tech Industrial Development Zone Community Health Service, Zhongshan, 528437, China

    Juran Chen

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  1. Huiqin Nie
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Contributions

HP and QL designed the study and drafted the primary manuscript. TY supervised the recruitment and made statistical analyses. TY, HN, JC, YL and XL took part in recruitment and data management. QL, HN, YZ and JX made further revisions of the manuscript. All the authors had read and approved the final manuscript.

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Correspondence to Qianyi Luo or Hongjun Peng.

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Nie, H., Yu, T., Zou, Y. et al. Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions. Brain Imaging and Behavior (2024). https://doi.org/10.1007/s11682-024-00859-w

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