Conflict adaptation and related neuronal processing in Parkinson’s disease
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Published:2021-08-27
Issue:1
Volume:16
Page:455-463
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ISSN:1931-7557
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Container-title:Brain Imaging and Behavior
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language:en
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Short-container-title:Brain Imaging and Behavior
Author:
Rodriguez-Raecke ReaORCID, Schrader Christoph, Tacik Pawel, Dressler Dirk, Lanfermann Heinrich, Wittfoth Matthias
Abstract
AbstractNon-motor symptoms like cognitive impairment are a huge burden for patients with Parkinson’s disease. We examined conflict adaptation by using the congruency sequence effect as an index of adaptation in 17 patients with Parkinson’s disease and 18 healthy controls with an Eriksen flanker task using functional magnet resonance imaging to reveal possible differences in executive function performance. We observed overall increased response times in patients with Parkinson’s disease compared to healthy controls. A flanker interference effect and congruency sequence effect occurred in both groups. A significant interaction of current and previous trial type was revealed, but no effect of response sequence concerning left or right motor responses. Therefore, top-down conflict monitoring processes are likely the main contributors leading to the congruency sequence effect in our paradigm. In both groups incongruent flanker events elicited activation in the middle temporal gyrus, inferior parietal cortex, dorsolateral prefrontal cortex and the insula in contrast to congruent flanker events. A psychophysiological interactions analysis revealed increased functional connectivity of inferior parietal cortex as a seed to the left prefrontal thalamus during incongruent vs. congruent and neutral stimuli in patients with Parkinson’s disease that may reflect compensatory facilitating action selection processes. We conclude that patients with Parkinson’s disease exhibit conflict adaptation comparable to healthy controls when investigated while receiving their usual medication.
Funder
International Parkinson Fonds Universitätsklinikum RWTH Aachen
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Psychiatry and Mental health,Cellular and Molecular Neuroscience,Neurology (clinical),Cognitive Neuroscience,Neurology,Radiology, Nuclear Medicine and imaging
Reference35 articles.
1. Adam, J. J., Scholtissen, B., & Mari-Beffa, P. (2012). Response preparation in Parkinson’s disease: Automatic vs. controlled processing. Acta Psychologica (Amsterdam), 139(3), 465–470. https://doi.org/10.1016/j.actpsy.2012.01.008 2. Bonnin, C. A., Houeto, J. L., Gil, R., & Bouquet, C. A. (2010). Adjustments of conflict monitoring in Parkinson’s disease. Neuropsychology, 24(4), 542–546. https://doi.org/10.1037/a0018384 3. Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001). Conflict monitoring and cognitive control. Psychological Review, 108(3), 624–652. https://doi.org/10.1037/0033-295x.108.3.624 4. Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S., & Cohen, J. D. (1999). Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature, 402(6758), 179–181. https://doi.org/10.1038/46035 5. Cagigas, X. E., Filoteo, J. V., Stricker, J. L., Rilling, L. M., & Friedrich, F. J. (2007). Flanker compatibility effects in patients with Parkinson’s disease: Impact of target onset delay and trial-by-trial stimulus variation. Brain and Cognition, 63(3), 247–259. https://doi.org/10.1016/j.bandc.2006.09.002
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