Abstract
AbstractIn recent decades, the therapeutic potential of cannabinoids and analogous compounds has been intensively investigated. The endocannabinoid system has already been identified in the skin and, although much remains to be discovered about its contribution and importance for the maintenance of skin homeostasis, it has been increasingly associated as promising for dermatological disorders’ management. Cannabidiol (CBD), the main non-intoxicating phytocannabinoid in cannabis, has been shown to have hydrating, sebostatic, antipruritic, antimicrobial, anti-inflammatory, antioxidant, wound healing, photoprotective, anti-fibrotic and antitumoral, as well as modulating hair growth. Thus, CBD has gained attention concerning its application in cutaneous pathologies such as atopic dermatitis, psoriasis, acne, epidermolysis bullosa, systemic sclerosis, seborrheic dermatitis, androgenetic alopecia and cutaneous melanoma, although its bioactivities still lack scientific evidence and some of its mechanisms of action remain to be elucidated. Given its physicochemical characteristics, its topical administration becomes challenging, and it is necessary to develop new technological strategies to overcome the skin intact barrier. This review describes the latest evidence that exists on the application of CBD to the skin, the problems inherent to its chemical structure and that compromise its cutaneous administration, and the different strategies and formulations that have been studied to improve it, also clarifying some CBD-containing cosmetics products that are already available on the market.
Graphical Abstract
Publisher
Springer Science and Business Media LLC
Subject
Plant Science,Biotechnology
Reference208 articles.
1. Elitou, E. This "Becalm" Balm Uses CBD to Soothe Everything from Burns to Stressed-out Skin. 2020 [cited 2022 20 de agosto ]; Available from: https://www.byrdie.com/deawy-cbd-burn-balm-launch-5085906.
2. Xue F, Exclusive: Saint Jane Debuts New "C-Drops" Serum. 2022 [cited 2022 20 de agosto ]; Available from: https://www.byrdie.com/saint-jane-c-drops-serum-4800703.
3. Abdel-Hafez SM, Hathout RM, Sammour OA (2018) Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy. Int J Biol Macromol 108:753–764. https://doi.org/10.1016/j.ijbiomac.2017.10.170
4. Abichabki N, Zacharias LV, Moreira NC, Bellissimo-Rodrigues F, Moreira FL, Benzi JRL, Ogasawara TMC, Ferreira JC, Ribeiro CM, Pavan FR, Pereira LRL, Brancini GTP, Braga GUL, Zuardi AW, Hallak JEC, Crippa JAS, Lanchote VL, Canton R, Darini ALC, Andrade LN (2022) Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli. Sci Reports. https://doi.org/10.1038/s41598-022-10393-8
5. Aguillon AR, Leao RAC, Miranda LSM, de Souza R (2021) Cannabidiol discovery and synthesis-a target-oriented analysis in drug production processes. Chem-a Eur J 27(18):5577–5600. https://doi.org/10.1002/chem.202002887
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献