Lessons for the clinical nephrologist: a rare case with MGRS characterized by combined crystalline light chain proximal tubulopathy and crystal-storing histiocytosis responding to daratumumab

Author:

Qin Ai-boORCID,Yu Xiao-juan,Zheng Xi-zi,Wang Su-xia,Zhou Fu-de,Zhao Ming-hui

Funder

the National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Nephrology

Reference9 articles.

1. Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D’Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH (2019) The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15(1):45–59. https://doi.org/10.1038/s41581-018-0077-4

2. Sethi S, Rajkumar SV, D’Agati VD (2018) The complexity and heterogeneity of monoclonal immunoglobulin-associated renal diseases. J Am Soc Nephrol 29(7):1810–1823. https://doi.org/10.1681/asn.2017121319

3. Klomjit N, Leung N, Fervenza F, Sethi S, Zand L (2020) Rate and predictors of finding Monoclonal Gammopathy of Renal Significance (MGRS) lesions on kidney biopsy in patients with monoclonal gammopathy. J Am Soc Nephrol 31(10):2400–2411. https://doi.org/10.1681/asn.2020010054

4. Yong ZH, Yu XJ, Liu JX, Zhou FD, Wang SX, Zhao MH (2022) Kidney histopathologic spectrum and clinical indicators associated with MGRS. Clin J Am Soc Nephrol 17(4):527–534. https://doi.org/10.2215/cjn.12890921

5. Fang H, Chiu A, Reichard KK (2018) Crystal-storing histiocytosis in bone marrow: a clinicopathologic study of eight cases and review of the literature. Am J Clin Pathol 149(2):148–163. https://doi.org/10.1093/ajcp/aqx150

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