Abstract
AbstractElectrospinning is a promising technique for preparing bioartificial blood vessels. Nanofibers prepared by electrospinning can simulate the structure of extracellular matrix to promote cell adhesion and proliferation. However, thorn-like protrusions can appear as defects on electrospun scaffolds and coaxial electrospun nanofibers often have no clear core/shell structure, which can seriously affect the quality of bioartificial blood vessels. To address these problems, Tween 80 is added to the electrospinning solution, which results in a stable Taylor cone, eliminates the thorn-like protrusions on electrospun bioartificial blood vessels, and reduces interfacial effects due to different core/shell solutions during coaxial electrospinning. Simulations, biomechanical tests, and in vivo studies were performed. The results demonstrate the excellent mechanical properties and biocompatibility of the bioartificial blood vessel. This research provides a useful reference for optimizing the electrospinning process for fabricating bioartificial blood vessels.
Graphical Abstract
Funder
Innovative Science and Technology Platform Project of Cooperation between Yangzhou City and Yangzhou University, China
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Biomaterials,Bioengineering,Biophysics
Reference47 articles.
1. Raushan K, Syed Ibrahim R. The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia. In Nutraceutical and Functional Foods in Disease Prevention, Raj, KK; Anil, KS; Rajesh, KK, Eds. IGI Global: Hershey, PA, USA, 2019; pp 233–54.
2. Zhang X, Liu H, Hao Y, Xu L, Zhang T, Liu Y, et al. Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice. Lipids in Health and Dis. 2018;17(1):279.
3. Lopes SV, Collins MN, Reis RL, Oliveira JM, Silva-Correia J. Vascularization approaches in tissue engineering: Recent developments on evaluation tests and modulation. ACS Appl Bio Mater. 2021;4(4):2941–56.
4. Mladěnka P, Applová L, Patočka J, Costa VM, Remiao F, Pourová J, et al. Comprehensive review of cardiovascular toxicity of drugs and related agents. 2018;38(4):1332–403.
5. Esmaeili S, Shahali M, Kordjamshidi A, Torkpoor Z, Namdari F, Samandari SS, et al. An artificial blood vessel fabricated by 3D printing for pharmaceutical application. 2019;6(3):183–94.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献