New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions
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Published:2023-06-27
Issue:3
Volume:42
Page:891-925
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ISSN:0167-7659
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Container-title:Cancer and Metastasis Reviews
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language:en
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Short-container-title:Cancer Metastasis Rev
Author:
Zhang Chunxue, Sheng Yaru, Sun Xiao, Wang YudongORCID
Abstract
AbstractAdvanced and recurrent gynecological cancers lack effective treatment and have poor prognosis. Besides, there is urgent need for conservative treatment for fertility protection of young patients. Therefore, continued efforts are needed to further define underlying therapeutic targets and explore novel targeted strategies. Considerable advancements have been made with new insights into molecular mechanisms on cancer progression and breakthroughs in novel treatment strategies. Herein, we review the research that holds unique novelty and potential translational power to alter the current landscape of gynecological cancers and improve effective treatments. We outline the advent of promising therapies with their targeted biomolecules, including hormone receptor-targeted agents, inhibitors targeting epigenetic regulators, antiangiogenic agents, inhibitors of abnormal signaling pathways, poly (ADP-ribose) polymerase (PARP) inhibitors, agents targeting immune-suppressive regulators, and repurposed existing drugs. We particularly highlight clinical evidence and trace the ongoing clinical trials to investigate the translational value. Taken together, we conduct a thorough review on emerging agents for gynecological cancer treatment and further discuss their potential challenges and future opportunities.
Funder
Program of Shanghai Academic Research Leader Shanghai Municipal Key Clinical Specialty International Science and Technology Cooperation Project Shanghai Shenkang Hospital Development Center, Clinical Technology Innovation Project Shanghai Jiao Tong University Medicine-Engineering Fund
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
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