Resveratrol as sensitizer in colorectal cancer plasticity
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Published:2023-07-29
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Volume:
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ISSN:0167-7659
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Container-title:Cancer and Metastasis Reviews
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language:en
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Short-container-title:Cancer Metastasis Rev
Author:
Brockmueller ArankaORCID, Sajeev Anjana, Koklesova LenkaORCID, Samuel Samson MathewsORCID, Kubatka PeterORCID, Büsselberg DietrichORCID, Kunnumakkara Ajaikumar B.ORCID, Shakibaei MehdiORCID
Abstract
Abstract
Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments.
Graphical abstract
Funder
Ludwig-Maximilians-Universität München
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Reference341 articles.
1. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA: a Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660 2. Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022). Cancer statistics, 2022. CA: a Cancer Journal for Clinicians, 72(1), 7–33. https://doi.org/10.3322/caac.21708 3. Sadahiro, S. (1987). A study of tumor-associated cellular proteins from carcinoma and adenoma of the human colon. Nihon Geka Gakkai Zasshi, 88(5), 551–561. 4. Welch, J. P., & Donaldson, G. A. (1974). Perforative carcinoma of colon and rectum. Annals of Surgery, 180(5), 734–740. https://doi.org/10.1097/00000658-197411000-00005 5. Donadon, M., Ribero, D., Morris-Stiff, G., Abdalla, E. K., & Vauthey, J. N. (2007). New paradigm in the management of liver-only metastases from colorectal cancer. Gastrointestinal Cancer Research: GCR, 1(1), 20–27.
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