Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts
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Published:2023-06-07
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ISSN:1018-8827
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Container-title:European Child & Adolescent Psychiatry
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language:en
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Short-container-title:Eur Child Adolesc Psychiatry
Author:
Cheng Xiaofang,Chen Jianshan,Zhang Xiaofei,Wang Ting,sun Jiaqi,Zhou Yanling,Yang Ruilan,Xiao Yeyu,Chen Amei,Song Ziyi,Chen Pinrui,Yang Chanjuan,QiuxiaWu ,Lin Taifeng,Chen Yingmei,Cao Liping,Wei Xinhua
Abstract
AbstractConverging evidence has revealed disturbances in the corticostriatolimic system are associated with suicidal behaviors in adults with major depressive disorder. However, the neurobiological mechanism that confers suicidal vulnerability in depressed adolescents is largely unknown. A total of 86 depressed adolescents with and without prior suicide attempts (SA) and 47 healthy controls underwent resting-state functional imaging (R-fMRI) scans. The dynamic amplitude of low-frequency fluctuations (dALFF) was measured using sliding window approach. We identified SA-related alterations in dALFF variability primarily in the left middle temporal gyrus, inferior frontal gyrus, middle frontal gyrus (MFG), superior frontal gyrus (SFG), right SFG, supplementary motor area (SMA) and insula in depressed adolescents. Notably, dALFF variability in the left MFG and SMA was higher in depressed adolescents with recurrent suicide attempts than in those with a single suicide attempt. Moreover, dALFF variability was capable of generating better diagnostic and prediction models for suicidality than static ALFF. Our findings suggest that alterations in brain dynamics in regions involved in emotional processing, decision-making and response inhibition are associated with an increased risk of suicidal behaviors in depressed adolescents. Furthermore, dALFF variability could serve as a sensitive biomarker for revealing the neurobiological mechanisms underlying suicidal vulnerability.
Funder
the STI 2030- Major projects
the Natural Science Foundation of Guangdong Province
Science and Technology Program of Guangzhou
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Developmental and Educational Psychology,General Medicine,Pediatrics, Perinatology and Child Health