Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect
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Published:2021-04-16
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Volume:
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ISSN:1018-8827
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Container-title:European Child & Adolescent Psychiatry
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language:en
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Short-container-title:Eur Child Adolesc Psychiatry
Author:
Böttinger Boris WilliamORCID, , Baumeister Sarah, Millenet Sabina, Barker Gareth J., Bokde Arun L. W., Büchel Christian, Quinlan Erin Burke, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Ittermann Bernd, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Artiges Eric, Orfanos Dimitri Papadopoulos, Paus Tomáš, Poustka Luise, Fröhner Juliane H., Smolka Michael N., Walter Henrik, Whelan Robert, Schumann Gunter, Banaschewski Tobias, Brandeis Daniel, Nees Frauke
Abstract
AbstractConduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.
Funder
Horizon 2020 Zentralinstitut für Seelische Gesundheit (ZI)
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Developmental and Educational Psychology,General Medicine,Pediatrics, Perinatology, and Child Health
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