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Pregnancy and neonatal outcomes in 25 pregnant women diagnosed with new-onset acute myeloid leukemia during pregnancy

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim was to analyze the pregnancy and neonatal outcomes of pregnant women with new- onset acute myeloid leukemia (AML) diagnosed during pregnancy.

Methods

In this retrospective study 25 pregnant women who were diagnosed with new-onset AML during pregnancy from January 2010 to January 2021 were enrolled.

Results

A total of 4, 13 and 8 pregnant women with new-onset AML were diagnosed during the first, second, and third trimesters, respectively. Twelve of the 25 pregnant women underwent therapeutic abortion and 13 gave birth (9 preterm and 4 full-term newborns). The gestational age at initial clinical manifestations (13.4 ± 3.7 vs. 27.7 ± 5.6 weeks, P < 0.01) and diagnosis (16.9 ± 4.4 vs. 29.7 ± 5.5 weeks, P < 0.01) was lower in the pregnant women who underwent therapeutic abortion than in those who gave birth. Eighty-four percent (21/25) of the pregnant women with new-onset AML during pregnancy survived and were in remission and all the newborns were born alive. Three of the 13 newborns were exposed to chemotherapy, but no congenital malformations were observed. Eight newborns were admitted to the neonatal intensive care unit (NICU), and all recovered. The complete blood counts and biochemical examinations of the 8 newborns were normal.

Conclusions

New-onset AML during an earlier stage of pregnancy may increase the risk of poor pregnancy outcomes. The neonatal outcomes of pregnant women with new-onset AML during pregnancy are good with proper treatment.

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Heading

The dataset supporting the conclusions of this article is available in the clinical data repository of Peking University People's Hospital. Individual participant data were not shared. For the original data, please contact dingjingvv@126.com.

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Funding

This study was supported by the Foundation of 2018 Beijing Key Clinical Specialty Construction Project-Pediatrics (2199000726).

Author information

Authors and Affiliations

  1. Department of Pediatrics, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China

    Jing Ding, YiHan Xiao & Jie Fu

  2. Department of Gynecology and Obstetrics, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China

    Guoli Liu

  3. Peking University Institute of Hematology, Peking University People’s Hospital, No.11, Xizhimen South Street, Beijing, 100044, People’s Republic of China

    Shanyamei Huang & Xiaodong Mo

Authors
  1. Jing Ding
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  4. Guoli Liu
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  6. Xiaodong Mo
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Contributions

D: protocol/project development, data collection, data analysis, manuscript writing. X, F, L and H: data collection, data analysis. M: project development, manuscript editing. All authors contributed to the study conception and design. The first draft of the manuscript was written by Jing Ding and all authors commented on previous versions of the manuscript. All the authors have read and approved the final manuscript.

Corresponding author

Correspondence to Xiaodong Mo.

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The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee (EC) of the Peking University People’s Hospital.

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Informed consent was obtained from all individual participants included in the study.

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Ding, J., Xiao, Y., Fu, J. et al. Pregnancy and neonatal outcomes in 25 pregnant women diagnosed with new-onset acute myeloid leukemia during pregnancy. Arch Gynecol Obstet (2024). https://doi.org/10.1007/s00404-024-07402-8

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